Table 8.

GRADE rating for quality of evidence and strength of recommendation regarding treatment options for MIH molars

Interventions for molars	No. of studies	No. of restorations /teetha	GRADE of evidence quality	Strength of Recommendation
Fissure sealants, applied with an adhesive, can be used in mild cases in fully erupted molars	3	184	Moderate	Strong
GIC restorations using a non-invasiveb approach may be used as in cases where the child cannot co-operate for conventional treatment	5	333	Moderate	Conditional
Composite resin restorations placed under rubber dam isolation, using an invasive b approach can be used as a restorative option in mild/severe cases	8	793	Moderate	Strong
Non-invasive b composite restorations should not be placed	2	189	Moderate	Strong
The use of self-etch, total etch or deproteinisation with sodium hypochlorite is unlikely to make a difference to the retention rate of a composite restoration	3	137	Moderate	Strong
PMCs can be placed in severe cases	3	88	Moderate	Strong
Laboratory manufactured restorations using an invasive approach can be used as a restorative option in severe cases	4	132	Moderate	Conditional
Good space closure can be achieved spontaneously following extraction of affected molars	3	189	Moderate	Conditional

^aDrop-outs have not been excluded as it was not possible to ascertain the number in all of the studies due to mixed data

^bNon-invasive—preservation of affected enamel; invasive—removal of all hypomineralised enamel to achieve margin on clinically sound enamel