Table 5.
Summary of drug-related adverse events (AEs) (safety set)
| HSK3486 (n = 135) | Propofol (n = 132) | P-value | |
|---|---|---|---|
| Increased serum bilirubin | 2 (1.5) | 3 (2.3) | 0.9798 |
| Somnolence | 2 (1.5) | 3 (2.3) | 0.9798 |
| Dizziness | 6 (4.4) | 8 (6.1) | 0.5536 |
| Hypoxia | 8 (5.9) | 3 (2.3) | 0.1332 |
| Hiccups | 0 (0.0) | 1 (0.8) | 0.494 |
| Erythematous rash | 0 (0.0) | 1 (0.8) | 0.494 |
| Rash | 1 (0.7) | 0 (0.0) | 1.000 |
| Pruritus | 0 (0.0) | 2 (1.5) | 0.244 |
| Cry | 1 (0.7) | 0 (0.0) | 1.000 |
| Pain on injection | 6 (4.4) | 52 (39.4) | < 0.001 |
| Vomiting | 0 (0.0) | 1 (0.8) | 0.494 |
| Bradycardia/sinus bradycardia | 10 (7.4) | 11 (8.3) | 0.823 |
| Hypotension | 30 (22.2) | 37 (28.0) | 0.323 |
Data are given as numbers with percentage in parentheses