Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 1;36(3):283–300. doi: 10.1007/s40263-021-00895-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Fig. 3 — Schematic structure of the final model. EC₅₀ concentration producing 50% of maximum drug effect, E_max maximum drug effect, k_deg receptor degradation rate constant, k_e(L) elimination rate constant for ligand, k_e(P) elimination rate constant for complex, k_in B cell input rate, k_off dissociation rate constant, k_on binding rate, k_out B cell elimination rate constant, k_syn synthesis rate constant, L ligand, Q intercompartmental flow, QB flow between B cell compartments, V_b peripheral volume of distribution of B cells, V_c central volume of distribution, V_p peripheral volume of distribution of ofatumumab