Table 4.

PK and B cell metrics as a function of baseline weight, age, and B cell count

	Covariate	AUC (mg day/L)	B cell count at 2 years (day 728) (cells/µL)	Time to LLN (days)
Percentiles	Weight (kg)
5th	50	57.2 [17.8–129.1]	1.1 [0.3–5.8]	204.0 [82.0–480.0]
Median	70	33.3 [10.6–76.8]	1.3 [0.4–7.3]	164.0 [61.1–425.8]
95th	110	16.0 [3.4–37.4]	1.6 [0.5–30.8]	128.0 [32.9–364.0]
	Age (years)
Minimum	18	34.4 [11.7–80.1]	1.6 [0.5–8.6]	156.0 [52.0–388.4]
Median	38	34.6 [9.5–78.3]	1.4 [0.4–9.8]	160.0 [54.5–412.0]
Maximum	56	34.4 [10.2–81.8]	1.2 [0.3–7.1]	172.0 [70.0–454.4]
	Cell count (cells/µL)
5th	80	33.0 [11.5–75.9]	1.6 [0.5–7.7]	164.0 [58.0–424.0]
Median	200	34.7 [9.6–76.1]	1.3 [0.4–8.5]	164.0 [52.0–422.4]
95th	460	33.5 [10.8–80.4]	1.1 [0.3–10.9]	162.0 [58.0–435.8]

AUC area under the curve, LLN lower limit of normal (40 cells/µL), PK pharmacokinetic