Table 3.
Hematological and renal response to eculizumab therapy in six sTMA patients
| Characteristic | Baseline | 4 weeks | 6 months | Last FU |
|---|---|---|---|---|
| Anemia | 6 (100%) | 6 (100%) | 4 (66.6%) | 5 (83.3%) |
| Mean Hb (g/dL) | 8.2 (± 1.4) | 9.6 (± 1) | 11.4 (± 1.1) | 10.8 (± 2.2) |
| Thrombopenia | 5 (83.3%) | 4 (66.7%) | 1 (25%) | 2 (33.3%) |
| Mean PLT count (G/L) | 100 (± 139) | 122 (± 128) | 191 (± 69) | 177 (± 94) |
| Mean LDH (U/L) | 635 (± 378) | 528 (± 530) | 221 (± 82) | 388 (± 445) |
| AKI | 6 (100%) | n.a | n.a | n.a |
| RRT | 4 (66.7%) | 3 (50%) | 1 (16.6%) | 1 (16.6%) |
| Mean SCr (mg/dL) | 3.8 (± 1.87) | 3.56(± 0.74) | 2.69 (± 0.54) | 2.18 (± 0.44) |
| Mean PKR (mg/g) | 694 (± 969) | n.a.a | 428 (± 226) | 196 (± 95) |
| KTX | 0 | 0 | 0 | 0 |
| Patients on Ecu therapy | 6 (100%) | 4 (66.6%) | 2 (33.3) | 0 |
| Lost to FU | 0 | 0 | 0 | 2 (33.3%) |
Numbers are count and percent or mean and standard deviation
sTM secondary thrombotic microangiopathy, FU follow-up, Hb hemoglobin, PLT platelets, LDH lactate dehydrogenase, SCr serum creatinine, PKR protein-creatinine ratio, RRT renal replacement therapy, KTX kidney transplantation, Ecu eculizumab
aData only available for 1 patient. Anemia was defined as Hb levels of < 12.5 g/dL for female and < 13.5 g/dL for male patients. Thrombopenia was defined as platelet count < 150 G/L