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Reasons for dose reduction according to each TKI.
| First-line(N=116) | Second-line(N=63) | Third-line or later(N=15) | Overall(N=194) | |
|---|---|---|---|---|
| Imatinib, n (AEs/MR) | 47/32 | 3/0 | 0/1 | 50/33 |
| Nilotinib, n (AEs/MR) | 12/15 | 16/19 | 5/2 | 33/36 |
| Dasatinib, n (AEs/MR) | 6/4 | 12/10 | 4/0 | 22/14 |
| Bosutinib, n (AEs/MR) | – | – | 2/0 | 2/0 |
| Ponatinib, n (AEs/MR) | – | 1/2 | 1/0 | 2/2 |
AEs, adverse events; MR,molecular response.
