Table 3.
Changes of nutritional parameters as continuous variables in the IDPN group compared with the control group (between groups comparison).
| Parameters | Difference of changes between groups from 0 to 3 months absolute change [95% CI] | P value* | Absolute values from month 3 to 6 in the control group (n = 19) | Absolute values from month 3 to 6 in the IDPN group (n = 18) | Difference of changes between groups from 3 to 6 months absolute change [95% CI] | p value* |
|---|---|---|---|---|---|---|
| Primary outcome | ||||||
| Serum albumin, g/dL | 0.3 [0.2 to 0.4] | < 0.001 | 3.5 ± 0.3 to 3.6 ± 0.2 | 3.8 ± 0.2 to 3.7 ± 0.2 | − 0.1 [− 0.3 to 0.04] | 0.14 |
| Secondary outcomes | ||||||
| Oral energy intake, kcal/kg/day | 4.9 [1.6 to 8.3] | 0.005 | 20.0 ± 5.0 to 21.7 ± 8.7 | 21.4 ± 5.7 to 22.6 ± 8.7 | − 2.9 [− 8.7 to 2.9] | 0.31 |
| Oral protein intake, g/kg/day | 0.2 [− 0.04 to 0.3] | 0.13 | 0.8 ± 0.3 to 0.9 ± 0.3 | 0.9 ± 0.2 to 0.9 ± 0.2 | − 0.2 [− 0.4 to 0.01] | 0.06 |
| Serum prealbumin, mg/dL | − 2.3 [− 6.5 to 1.8 ] | 0.26 | 30.0 ± 6.7 to 29.6 ± 7.8 | 28.4 ± 6.8 to 29.3 ± 7.5 | 2.1 [− 0.9 to 5.2] | 0.17 |
| Body weight, kg | 1.4 [− 0.1 to 2.8] | 0.06 | 56.1 ± 11.4 to 56.5 ± 11.3 | 61.2 ± 11.9 to 60.8 ± 12.2 | − 0.1 [− 1.7 to 1.5] | 0.89 |
| BMI, kg/ m2 | 0.4 [− 0.3 to 1.0] | 0.28 | 22.4 ± 4.4 to 22.6 ± 4.6 | 22.6 ± 3.7 to 22.7 ± 3.9 | − 0.2 [− 0.8 to 0.3] | 0.42 |
| Total-body muscle mass, kg | − 0.8 [− 2.3 to 0.7] | 0.27 | 20.2 ± 3.8 to 20.4 ± 3.5 | 19.7 ± 3.6 to 20.1 ± 4.5 | 2.3 [− 1.8 to 6.4] | 0.25 |
| Appendicular muscle mass, kg | − 0.4 [− 2.0 to 1.1] | 0.56 | 14.7 ± 3.2 to 14.3 ± 2.9 | 14.2 ± 3.3 to 14.4 ± 4.0 | 2.2 [− 1.1 to 5.7] | 0.18 |
| Handgrip strength, kg | 0.2 [− 4.6 to 5.0] | 0.92 | 14.0 ± 7.0 to 12.0 ± 4.7 | 12.5 ± 6.1 to 11.6 ± 6.7 | 1.2 [− 2.9 to 5.2] | 0.56 |
| MIS, points | − 1.3 [− 2.9 to 0.4] | 0.12 | 7.0 ± 2.9 to 7.3 ± 3.0 | 6.8 ± 3.2 to 8.2 ± 4.0 | 1.0 [− 0.5 to 2.6] | 0.19 |
| Normalized PCR, g/kg/day | − 0.1 [− 0.4 to 0.02] | 0.08 | 1.2 ± 0.4 to 1.0 ± 0.3 | 1.2 ± 0.2 to 1.1 ± 0.3 | − 0.01 [− 0.5 to 0.5] | 0.98 |
BMI Body mass index, CI Confidence interval, MIS Malnutrition inflammation score, PCR Protein catabolic rate.
*P values for between group comparison of changes using linear regression model.
(−) indicated a decrease value.