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. 2022 Mar 16;13:1373. doi: 10.1038/s41467-022-29040-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative H&E image of a TLS in EC, which were observed in 29 of the 273 cases of the Uterine Corpus Endometrial Carcinoma (UCEC) cohort of The Cancer Genome Atlas (TCGA) research consortium. b Frequency of molecular subgroups by TLS status in endometrial cancer patients included in the UCEC TCGA. Source data are available at: https://portal.gdc.cancer.gov. c Differential gene expression of TLS-positive versus TLS-negative TCGA UCEC cases. d Representative L1CAM-positive TLS case. Arrows indicate TLS. e Co-immunofluorescent analysis of L1CAM-positive TLS with L1CAM and CD21. The experiment was repeated four times with similar results. n Number of cases, POLEmut Pathogenic polymerase epsilon mutation, MMRd Mismatch repair-deficient, p53abn p53 abnormal, NSMP No specific molecular profile, TLS Tertiary lymphoid structure, L1CAM Ligant-1 cell adhesion molecule, DAPI 4′,6-diamidino-2-phenylindole. Source data are provided as a Source Data File.