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. 2022 Mar 16;12:108. doi: 10.1038/s41398-022-01868-3

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© The Author(s) 2022, corrected publication 2022

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Fig. 4 — BMI, body mass index; WHR, waist-hip-ratio; Sum_Anxiety, sum score of 10 items related to anxiety from MINI; Sum_Depression, sum score of 10 items related to depression from MINI; NumCigarette, number of cigarettes per day; DailyALC, daily alcohol intake; Drug Freq, lifetime drug use frequency; Soft Drug Freq, lifetime soft drug use frequency; Hard Drug Freq, lifetime hard drug use frequency; r_G: genetic correlation; r_P: phenotypic correlation. r_G and r_P adjusted for age, age² and sex. P-value(0): the difference of r_G /r_P from 0, ***p < 0.001, **p < 0.01, *p < 0.05. We also test the difference of r_G from 1, only r_G between Numcigarette and Packyears had non-significant difference from 1.