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. 2022 Mar 16;12:4512. doi: 10.1038/s41598-022-08442-3

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of tributyrin (TB) to mice undergoing desiccating stress protects against corneal barrier disruption and loss of conjunctival goblet cells. (A) Representative images of corneal permeability to Oregon-green-dextran (OGD) of four different animals from each treatment group. (B) Corneal epithelium permeability to OGD was quantified by measuring the mean fluorescence intensity. Each data point represents the average value from both eyes of one animal, n = 8–15 animals. (C) Representative images of conjunctival cryosections with PAS-stained goblet cells (purple-magenta) from TB and vehicle control-treated (PBS) mice. Area demarcated by the square is high magnification of the area underneath. (D) Accumulative data for conjunctival goblet cell number per mm, n = 8–9. (E) Representative images of corneal permeability to Oregon-green-dextran (OGD) of animals from each treatment group. (F) Corneal epithelium permeability to OGD for wild-type (WT) and Slc5a8 knockout (KO) mice gavaged with either vehicle control or tributyrin. Statistical comparisons were made using two-way ANOVA using Tukey’s multiple comparisons test. P value greater than 0.05 was considered non-significant (ns).