Table 2.
Cre mouse lines and their usefulness for pericyte studies
| Cre mouse lines | Targets | Their usefulness for pericyte studies | References |
|---|---|---|---|
| In neural and SCI system | |||
| Wnt1-Cre, Sox10-Cre mice crossed to Rosa26(eYfp) | Tagging of Neural crest-derived MSC | Neural crest-derived perivascular cells | 61 |
| Foxg1(cre/+);Tgfbr2(flox/flox) (Tgfbr2-cKO) | Ko of Tgfbr2 | Brain vessel development | 64 |
| Glial fibrillary acidic protein (GFAP)-cre | Ko of beta1-integrin (beta1-itg) | Perivascular astrocyte, blood–brain barrier | 71 |
| Nestin-Cre | Ko of CLEC-2 | Maturation and integrity of the developing vasculature | 67 |
| Wnt1-cre | Ko of Ctnnb1 (beta-catenin) | Pituitary vasculature, neural crest-derived pericytes | 60 |
| NG2-CreERT:R26R-tdTomato | Ko of Ninj1 gene | Schwann cells and microvasculature | 69 |
| Zeb2 (Sip1/Zfhx1b) Ko with Tie2-Cre and Vav-iCre | Ko of Zeb2 (Sip1/Zfhx1b) | Pericyte coverage of the cephalic vasculature | 63 |
| R26R with SM22alpha-Cre | Ko of BMPR1A or MMP2 | Brain microvessels | 41 |
| In skeletal system | |||
| Tie2-Cre mice with R26Rosa-lox-Stop-lox-LacZ | Tagging of endothelial cells | Endothelial cells | 73 |
| Ocn-Cre, Dmp1-Cre and Cxcl12(gfp) | Tagging Cxcl12(gfp) expressing cells | Cxcl12-abundant reticular cells and arteriolar pericytes | 74 |
| Rosa26-YFP-Sox10-Cre | Tagging of YFP-positive PCs and vSMCs | PCs, vascular smooth muscle cells (vSMC) | 70 |
| Rosa26R-LacZ | Osterix-expressing osteoblast precursors | Coupled vascular and osteogenic transformation | 68 |
| Wnt1-Cre-Tom and GLAST-CreERT2-Tom | GLAST+ Wnt1-traced pericytes | Bone marrow pericytes | 75 |
| Msx1(lacZ), Msx2(lox) and Sm22alpha-Cre | Ko of Msx1(CreERT2) | Vascular smooth muscle cells (vSMC) in arteries | 66 |
| PDGFRalpha or PDGFRbeta Ko with SM22alpha-Cre | Ko of PDGFRalpha or PDGFRbeta | Vascular smooth muscle cells (vSMC) development | 62 |
| Bmp2 floxed/3.6Col1a1-Cre [Bmp2-cKO(od)] | Ko of Bmp2 gene in odontoblasts | Odontoblasts on vascular bed and associated pericytes | 72 |
| Alpha-SMA-GFP transgenic | Bone marrow stromal cells | Vascularization in bone microenvironment | 58 |
| Other pericyte-related systems | |||
| Myh11-Cre(ERT2)tdTomato | Ko of KLF4 | Smooth muscle cells or pericytes in adipose tissue | 57 |
| LysM-Cre | Ko of NG2 | Tumor vascularization | 59 |
| Foxd1-Cre; Rs26-tdTomato | Foxd1 progenitor-derived pericytes | Myofibroblast precursor | 65 |