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. 2022 Jan 12;126(6):937–947. doi: 10.1038/s41416-021-01621-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Network interaction of the significant genes (FC > ±2.0 and p < 0.05) in cSI and cSII/III patients irrespective of localisation (TF and TC). Two distinct gene clusters were observed (red circle—interleukin cluster and green circle—integrin cluster). The network nodes represent proteins (encoded by the corresponding genes). b Ingenuity upstream regulator analysis predicted IL-6 as one of the top upstream regulators of gene expression in TF. The target genes of IL-6 identified in the dataset analysis are displayed in the figure. c Regulator effect network analysis by IPA identified IL-6 as an upstream regulator altering the expression of genes in the dataset that drive the invasion of tumour cells.