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. 2022 Mar 16;12:4464. doi: 10.1038/s41598-022-08445-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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O-GlcNAcylation and Akt phosphorylation levels in cervical cancer tissues. (a) Tissues were stained with Hematoxylin/Eosin (HE). Indirect inmunofluorescence was performed using indicated primary antibodies followed by secondary antibodies (FITC-conjugated anti-mouse and biotinylated anti-rabbit/Alexa Fluor 594). Representative merged images of immunofluorescence staining for O-GlcNAc (green), P-Akt (red) and cell nuclei (blue) of normal and cervical cancer-tissues are shown. The histograms display the relative quantification of the mean fluorescence integrated density by Image J software. Data are means ± SEM of n = 5 tissues, analysing each tissue in at least 3 different optical fields. Statistical analysis was performed using a Student’s t-test. *p < 0.05. (b) Positive correlation between O-GlcNAc and phopho-Akt signals in samples from normal and cervical cancer-tissues evaluated by Pearson analysis.