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. 2022 Mar 16;13:1395. doi: 10.1038/s41467-022-29109-7

Fig. 6. Multiple defects are observed in spermatozoa from male homozygous Cep128 KI mice.

Fig. 6

a Male homozygous KI mice showed hyperplasia of sperm flagella (n = 3 biologically independent WT mice or KI mice; scale bars, 20 µm). b Dislocated arrangements of MTDs 1‒3 and ODFs 1‒3 were exhibited in the majority of the midpieces. ODF outer dense fibers, MTD peripheral microtubule doublets. (n = 3 biologically independent WT mice or KI mice; scale bars, 150 nm). c Impaired development of the connecting piece during spermiogenesis in male homozygous Cep128 KO and KI mice. In spermatid steps 9–14, PCs with incomplete structure were present in both male homozygous KO and KI mice. Signs of defective Sc formation were occasionally visible in spermatids from male homozygous KI mice, but not in KO mice. In contrast, the Bp was almost normal in both male homozygous KO and KI mice. PC proximal centriole, Sc segmented column, Bp basal plate. (n = 3 biologically independent WT mice, KO mice or KI mice; scale bars, 500 nm).