FIG. 1.
Concentration-dependent effect of atovaquone and proguanil on ΔΨm and respiration. (A) Concentration-dependent effect of atovaquone and proguanil on ΔΨm. Fluorescence intensity was quantitated by FACS analysis in the presence of various concentrations of atovaquone (■) and proguanil (●). The results are presented as percent inhibition of fluorescence intensity, using CCCP-mediated inhibition as 100%. (B) Concentration-dependent effect of atovaquone and proguanil on parasite respiration. The rate of O2 consumption by P. yoelii-infected erythrocytes was measured in the presence of various concentrations of proguanil (○) and atovaquone (□) independently. The results are plotted as percent inhibition of respiration. The error bars indicate standard deviations.