Table 4.
Interpretation of evidence in comparison to previously published meta-analysis.
| Region | Functioning | Reduced thickness pattern | WTC |
|---|---|---|---|
| Lobule I/II | Motor, vestibular | MSA (R, L), PSP (L) | |
| Lobule III | Motor, vestibular | MSA (R, L), PSP (L) | |
| Lobule IV | Motor, vestibular | ||
| Lobule V | Motor, somatosensory | ALS (R) | L |
| Lobule VI | Motor, language, spatial | ALS (L), AD (R) | L |
| Crus I | Language (R), working memory, executive function, affective | PSP (L), ALS (L), AD (R) | R, L |
| Crus II | Language (R), working memory, executive function, affective | AD (R), FTD (R, L), PSP (L), ALS (L) | S |
| Lobule VIIb | Executive, language, affective | FTD (R, L), PSP (L) | R, L |
| Lobule VIIIa | Motor, working memory, language | ALS (R) | R, L |
| Lobule VIIIb | Motor, somatosensory | ALS (R) | R, L |
| Lobule IX | Visuomotor, memory, affective | PSP (R) | L |
| Lobule X | Vestibular |
Hemispheric results are listed using L for left and R for right. Boldface cortical thickness patterns denote results that overlap with WTC-related regions shown in the rightmost column. WTC patterns that were nominally significant are listed, while regions that passed the false discovery rate.
MSA multiple system atrophy, PSP progressive supranuclear palsy, ALS amyotrophic lateral sclerosis, AD Alzheimer’s disease, FTD frontotemporal dementia, WTC World Trade Center responder.