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. 2022 Mar 16;12:4502. doi: 10.1038/s41598-022-08168-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Daily oral spermidine treatment did not alter insulitis in pancreatic islets of female diabetic mice. (a) Insulitis grading map: grade 0 (no insulitis), grade 1 (peri insulitis to 10% insulitis), grade 2 (10- 50% insulitis), grade 3 (50- 75% insulitis), grade 4 (75–100% insulitis), scale bar: 200 µm, 20-fold magnification. (b) Number of islets per grade normalized to total number of islets in each mouse. (c) Percentage of islets having < 10% insulitis and > 10% insulitis analyzed in diabetic ctrl mice and diabetic spd mice in accordance to insulitis grading (2 datapoints per mouse in each group), black triangles show diabetic ctrl mice and red circles show diabetic spd mice. Diabetic ctrl mice (n = 4) and diabetic spd mice (n = 4). Two-way ANOVA with Sidak’s post-hoc test to compare respective grades between ctrl and spd groups and Mann–Whitney U test to compare ctrl and spd groups were used as statistical analysis.