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. 2022 Mar 16;13(3):245. doi: 10.1038/s41419-022-04671-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Representative IF images of CD206 (M2 phenotype macrophages) and MPZ (Myelin) staining of SN shows that EPO treatment (5000 IU/kg/IP, immediately after surgery and on post-surgery day 1 and 2) effectively control phagocytosis of myelin debris and which significantly protects myelin breakdown as compared to saline treatment (normal saline, 0.1 ml/IP/mouse) and are depicted in magnified images (B) and the results of the integrated density of MPZ are depicted in the bar graph (C). M1 and M2 are random subset images of the SN section. D EPO treatment effectively improves %SFI. Each image represents six images from four different SN, a total of 24 images/group. Scale bar, 20 μm; magnification, 40x. One-way ANOVA, Tukey’s multiple comparisons test. Data were expressed as means ± SEM, ***P < 0.0002, Saline vs. sham; **P < 0.0021, EPO vs. sham, #P < 0.05, Saline vs. EPO, n = 4/group (CD206/MPZ staining analyses). Unpaired t-tests, n = 7/group (SFI analyses).