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. 2022 Mar 3;10:828916. doi: 10.3389/fcell.2022.828916

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Copyright © 2022 Wang, Manni, Bärenwaldt, Wieboldt, Kirchhammer, Ivanek, Stanczak, Zippelius, König, Rodrigues Manutano and Läubli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Siglec-E-deficient DCs showed enhanced phenotypic maturation. (A–C) Flow cytometry analysis of the expression levels of several DC maturation markers on CtrV Sp37A3 cells (black) and EKO Sp37A3 cells (blue), including MHC-I (A), MHC-II (B), and CD40 (C). (D) treatment of CtrV Sp37A3 cells (black) and EKO Sp37A3 cells (blue) with neuraminidase and maturation with LPS was measured by the expression of MHC II. (E–G) Maturation markers on spleen and tumor-infiltrating cDCs isolated from MC38 subcutaneous tumor models of CD11c^creSigE^fl mice (blue) and littermates (CD11c^wtSigE^fl, black) by flow cytometry. Data are presented as mean (±SD). Two-way ANOVA was used for two-way comparisons, and unpaired t test was used for one-way comparisons (*p < 0.0332, **p < 0.0021, ***p < 0.0002, and ****p < 0.0001).