Fig. 5.

A Pathways of the effect of curcumin on apoptosis of the cells. B The pathways showed the effect of hyperthermia on apoptosis of the cells. C Real-time PCR results showing changes in the expression of the P53 and CASPASE3 genes and the control group compared to MCF-7 cells with MNP-CMC-CUR, the TP53 gene is 2.5-fold, and the CASPASE3 gene is 1.5 times compared to untreated control. D MCF-7 cells treated by MNP-CMC-CUR and hyperthermia, the TP53 gene was 2.16 times higher, and the CASPASE3 gene was 3.11-fold higher untreated cells. One-way ANOVA. **p ≤ 0.05, ****p ≤ 0.0001