Table 1.
Length of telomeres (kb) in study subjects by the status of islet autoimmunity (IA) and type 1 diabetes (T1D) in the Environmental Determinants of Diabetes in the Young (TEDDY) study.
| Parameter | Islet autoimmunity (IA) | Type 1 diabetes (T1D) | ||||
|---|---|---|---|---|---|---|
| Matched pairs n (%) | IA cases (in kb) | IA controls (in kb) | Matched pairs n (%) | T1D cases (in kb) | T1D controls (in kb) | |
| Country | ||||||
| Finland | 63 (16.20%) | 5.07 ± 0.76 | 5.22 ± 0.77 | 23 (19.49%) | 5.09 ± 0.78 | 5.02 ± 0.93 |
| Germany | 13 (3.34%) | 5.13 ± 0.65 | 5.52 ± 1.08 | 5 (4.24%) | 5.39 ± 0.96 | 5.40 ± 0.27 |
| Sweden | 182 (46.78%) | 5.13 ± 0.76 | 4.94 ± 0.84 | 49 (41.53%) | 5.22 ± 0.87 | 5.05 ± 1.05 |
| U.S.A. | 131 (33.68%) | 5.24 ± 0.78 | 5.35 ± 0.84 | 41 (34.74%) | 5.16 ± 0.73 | 5.09 ± 0.84 |
| Family history of T1D | ||||||
| First-degree relative | 79 (20.31%) | 5.19 ± 0.64 | 5.19 ± 0.81 | 25 (21.19%) | 5.27 ± 0.84 | 5.07 ± 0.81 |
| General population | 310 (79.69%) | 5.15 ± 0.79 | 5.13 ± 0.87 | 93 (78.81%) | 5.16 ± 0.80 | 5.07 ± 0.96 |
| Sex | ||||||
| Female | 169 (43.44%) | 5.23 ± 0.73 | 5.21 ± 0.88 | 52 (44.07%) | 5.28 ± 0.75 | 5.09 ± 0.96 |
| Male | 220 (56.56%) | 5.10 ± 0.78 | 5.10 ± 0.84 | 66 (55.93%) | 5.10 ± 0.84 | 5.06 ± 0.91 |
Telomere length data were available on both case and matched control subjects in 389 IA pairs and 118 T1D pairs. Computel was used to estimate the telomere length from the whole-genome sequence (WGS) data.
Telomere length is presented as mean ± standard deviation (S.D.) in kb.