Table 3.
Association between age-adjusted telomere length in subjects by the status of islet autoimmunity (IA, GADA-first or mIAA-first) and T1D in relation to HLA haplogenotypes.
| HLA status | Odds ratio (95% CI) | P-value |
|---|---|---|
| Any IA (n = 389 NCC pairs) | ||
| Age-adjusted telomere length | 0.91 (0.75–1.12) | 0.377 |
| HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
| HLA-DR3/4 | 1.85 (1.23–2.78) | 0.003 |
| HLA-DR4/4 or HLA-DR4/X | 1.30 (0.84–2.02) | 0.236 |
| mIAA-first (n = 159 NCC pairs) | ||
| Age-adjusted telomere length | 1.23 (0.87–1.73) | 0.248 |
| HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
| HLA-DR3/4 | 3.73 (1.70–8.17) | 0.001 |
| HLA-DR4/4 or HLA-DR4/X | 2.59 (1.16–5.78) | 0.020 |
| GADA-first (n = 158 NCC pairs) | ||
| Age-adjusted telomere length | 0.83 (0.60–1.14) | 0.248 |
| HLA-DR3/3 or HLA-DR3/9 | Reference | Reference |
| HLA-DR3/4 | 0.91 (0.51–1.63) | 0.762 |
| HLA-DR4/4 or HLA-DR4/X | 0.69 (0.36–1.33) | 0.266 |
| T1D (n = 118 NCC pairs) | ||
| Age-adjusted telomere length | 1.03 (0.75–1.42) | 0.861 |
| HLA-DR3/3 or HLA-DR3/9 (Reference) | Reference | Reference |
| HLA-DR3/4 | 2.22 (0.97–5.10) | 0.060 |
| HLA-DR4/4 or HLA-DR4/X | 1.63 (0.71–3.73) | 0.249 |
Complete data were available on 389 nested case–control (NCC) pairs for IA and on 118 matched pairs for T1D.
Telomere length was adjusted for age when the sample was drawn.
Significant values are in [bold].