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. 2022 Mar 16;13:1386. doi: 10.1038/s41467-022-28892-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a C57BL6 mice received an injection of either AAV-hSyn-ChR2-EYFP or AAV-hSyn-EYFP into one of the cortical regions and an optic-fiber implant. b Five injection areas. IL infralimbic region, mPFC medial prefrontal cortex, oPFC orbital PFC, PrL prelimbic region, TT tenia tecta. c Coronal sections show a representative EYFP expression with the tip of an optic-fiber placement (the arrow) just above the IL. Coronal sections were adopted from Allen Mouse Brain Atlas^© of Allen Institute for Brain Science available at: https://mouse.brain-map.org/static/atlas. d Schematic showing a mouse in a conditioning chamber equipped with two levers for ICSS. e ICSS data: Responding on the left lever was rewarded with photostimulation (a 25-Hz 8-pulse train) in sessions 3–7 and 11–14, while no photostimulation in sessions 1–2 or 8–10. Each line shows lever-press data from a single mouse. mOrb medial orbital region, Cg2 cingulate area 2, vOrb ventral orbital region.