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. 2022 Mar 16;13:1386. doi: 10.1038/s41467-022-28892-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Change in BOLD signals upon viewing App-suggested video clips. b Change in BOLD signals upon viewing control clips. c Difference in BOLD signals between app-suggested clips and control clips. d Resting-state functional connectivity map with AM as seed. e Overlapping mPFC zone (BA32 and 9) between c and d. f Resting-state functional connectivity map of the mPFC (e) as seed. g Dynamic causal modeling analysis on the mPFC–AM circuit with a full-model structure involving three components consisting of four intrinsic connections, eight experimental modulation on these connections, and four direct inputs from experimental conditions. h Empirical Bayesian model reduction on the four intrinsic connection parameters indicated the fully connected model was the best intrinsic model (P(m | Y) = 0.70) in which mPFC and AM showed excitatory between-region connections and inhibitory within-region connections. i Empirical Bayesian model reduction on the sixteen full-model parameters showed the best model (P(m | Y) = 0.67) in which parameters with posterior probability >0.95 include: (1) intrinsic positive input from mPFC to AM; (2) intrinsic positive input from AM to mPFC; (3) self-inhibition of AM; (4) disinhibition of mPFC by App; and (5) disinhibition of mPFC by control-video viewing.