Table 2.
Molecular characteristics of PCCRCs versus DCRCs.
| Features | PCCRCs (n = 122) | DCRCs (n = 98) | P value* | FDR** |
|---|---|---|---|---|
| APC gene mutation | 37/93 (39.8) | 39/79 (49.4) | 0.268 | |
| BRAF gene mutation | 17/93 (18.3) | 8/79 (10.1) | 0.195 | |
| FBXW7 gene mutation | 8/93 (8.6) | 9/79 (11.4) | 0.723 | |
| KIT gene mutation | 19/93 (20.4) | 18/79 (22.8) | 0.851 | |
| KRAS gene mutation | 32/93 (34.4) | 24/79 (30.4) | 0.690 | |
| PIK3CA gene mutation | 16/93 (17.2) | 13/79 (16.5) | 1.000 | |
| PTEN gene mutation | 11/93 (11.8) | 6/79 (7.6) | 0.502 | |
| SMAD4 gene mutation | 8/93 (8.6) | 9/79 (11.4) | 0.723 | |
| TP53 gene mutation | 36/93 (38.7) | 38/79 (48.1) | 0.278 | |
| Gain of chromosome 13q | 52/105 (49.5) | 60/88 (68.2) | 0.303 | |
| Loss of chromosome 17p | 45/105 (42.9) | 42/88 (47.7) | 0.986 | |
| Loss of chromosome 18q | 49/105 (46.7) | 64/88 (72.7) | 0.107 | |
| MSI | 26/120 (21.7) | 9/94 (9.6) | 0.029 | – |
| CIMP high profile | 61/122 (50.0) | 32/98 (32.7) | 0.014 | – |
PCCRC post-colonoscopy colorectal cancer, DCRC detected colorectal cancer, FDR false detection rate, MSI microsatellite instability, CIMP CpG island methylator phenotype.
*P value < 0.05 considered significant; **FDR < 0.2 considered significant.