Table 3.
Molecular characteristics of PCCRCs with likely biological cause versus DCRCs.
| Features | Biological PCCRCs (n = 94) | DCRCs (n = 98) | P value* | FDR** |
|---|---|---|---|---|
| APC gene mutation | 24/68 (35.3) | 39/79 (49.4) | 0.121 | |
| BRAF gene mutation | 16/68 (23.5) | 8/79 (10.1) | 0.049 | |
| FBXW7 gene mutation | 7/68 (10.3) | 9/79 (11.4) | 1.000 | |
| KIT gene mutation | 13/68 (19.1) | 18/79 (22.8) | 0.733 | |
| KRAS gene mutation | 19/68 (27.9) | 24/79 (30.4) | 0.887 | |
| PIK3CA gene mutation | 11/68 (16.2) | 13/79 (16.5) | 1.000 | |
| PTEN gene mutation | 10/68 (14.7) | 6/79 (7.6) | 0.265 | |
| SMAD4 gene mutation | 4/68 (5.9) | 9/79 (11.4) | 0.378 | |
| TP53 gene mutation | 23/68 (33.8) | 38/79 (48.1) | 0.113 | |
| Gain of chromosome 13q | 37/78 (47.4) | 60/88 (68.2) | 0.179 | |
| Loss of chromosome 17p | 29/78 (37.2) | 42/88 (47.7) | 0.051** | |
| Loss of chromosome 18q | 34/78 (43.6) | 64/88 (72.7) | 0.062 | |
| MSI | 22/93 (23.7) | 9/94 (9.6) | 0.017 | – |
| CIMP high profile | 48/94 (51.1) | 32/98 (32.7) | 0.015 | – |
PCCRC post-colonoscopy colorectal cancer, DCRC detected colorectal cancer, FDR false detection rate, MSI microsatellite instability, CIMP CpG island methylator phenotype.
*P value < 0.05 considered significant; ** FDR < 0.2 considered significant.