Fig. 8. Indisulam is efficacious in the Th-MYCN transgenic mouse model of neuroblastoma.
a Waterfall plot showing the relative changes in tumour volume in the Th-MYCN transgenic mice treated for 7 days with indisulam (n = 3 mice) or vehicle control (n = 4 mice) measured by MRI. Note that the mice represented by the grey bars reached the tumour size study endpoint (palpation) before their Day 7 MRI scan and the data shown for these two mice are the relative changes in volume following day 3 of treatment with indisulam. b Survival of mice treated with vehicle (n = 6 mice) or indisulam (n = 6 mice). One mouse in indisulam treated group died on day 7. The autopsy revealed no presence of tumour but evidence of bowel obstruction. c Representative anatomical coronal T2-weighted MRI of the abdomen of Th-MYCN mice prior (day 0) and following seven days of treatment with indisulam or vehicle control. A dashed white line indicates the tumour circumference. Source data is provided as a Source Data File.