Table 3.
Cox proportional hazard regression analysis for long-term mortality.
| Characteristics | Univariable | Multivariable** | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age, per year increment | 1.017 (1.014–1.019) | <0.001 | 1.008 (1.006–1.011) | <0.001 |
| Sex (male) | 1.140 (1.049–1.238) | 0.002 | 1.152 (1.060–1.252) | 0.001 |
| BMI, per 1 kg/m2 increment | 0.976 (0.967–0.984) | <0.001 | 0.963 (0.955–0.972) | <0.001 |
| CCI, per 1 score increment | 1.190 (1.164–1.217) | <0.001 | 1.093 (1.066–1.121) | <0.001 |
| APACHE II score, per 1 increment | 1.096 (1.089–1.102) | <0.001 | 1.063 (1.055–1.070) | <0.001 |
| Presence of shock | 2.564 (2.367–2.778) | <0.001 | 1.732 (1.582–1.897) | <0.001 |
| Use of mechanical ventilation | 2.096 (1.890–2.325) | <0.001 | 1.199 (1.072–1.340) | 0.001 |
| Active cancer | 2.907 (2.637–3.206) | <0.001 | 2.633 (2.380–2.912) | <0.001 |
| RRT initiated during ICU admission | 2.305 (2.095–2.536) | <0.001 | 1.504 (1.356–1.668) | <0.001 |
| RRT for end-stage renal disease | 0.981 (0.772–1.246) | 0.875 | 0.938 (0.735–1.197) | 0.607 |
| CFB of day 1–3* | 1.096 (1.085–1.106) | <0.001 | 1.047 (1.037–1.058) | <0.001 |
| CFB of day 4–7* | 1.048 (1.033–1.064) | <0.001 | 1.094 (1.080–1.108) | <0.001 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; CCI, Charlson comorbidity index; APACHE II, acute physiology and chronic health evaluation II; RRT, renal replacement therapy; ICU, intensive care unit; CFB, cumulative fluid balance.
*
Per 1 liter increment.
**
Additionally adjusted for age, sex, BMI, CCI, APACHE II score, presence of shock, use of mechanical ventilation, active cancer, RRT initiated during ICU admission, CFB of day 1–3, and CFB of day 4–7.