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. 2022 Mar 3;13:844778. doi: 10.3389/fimmu.2022.844778

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Copyright © 2022 Zhang, Wang, Wu, Gao, Zhao, Liu, Yan, Dong, Wang, Ba, Ma, Jin, Du, Ji and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Stromal score, immune score, estimate score, tumor purity of TCGA dataset. (B) Relationship between m5CrLS-based stratification and TIMER2.0 of 6 immune cells. (C) Correlation of myeloid dendritic cells with m5CrLS scores. (D) Chemokines and cytokines associated with dendritic cells were differentially expressed between high and low m5CrLS score in TCGA dataset. (E) Differences in 29 immune cells between high and low m5CrLS score patients of TCGA dataset. (F) 7 steps of the anti-tumor immune response analyzed by TIP. (G) The expression level of immune checkpoint in TCGA dataset. (ns, non-significant. *p < 0.05, **p < 0.01, and ***p < 0.001).