Table 4.

Management of ICIs based on toxicity levels according to the current guidelines (50, 51).

Toxicity grade	Management
Grade 1	In general, ICIs can be continued with close monitoring for mild toxicities (with the exception of neurologic and some hematologic toxicities).
Grade 2	For moderate toxicities, ICIs should be held until symptoms and/or lab values revert to grade 1 level or lower. Corticosteroids may be offered.
Grade 3	For severe toxicity, patients should receive high-dose corticosteroids for at least six weeks. Extreme caution when restarting immunotherapy after a grade 3 toxicity is recommended, if it is restarted at all.
Grade 4	In general, very severe toxicity necessitates stopping checkpoint inhibitor therapy permanently.