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. 2022 Mar 3;13:819699. doi: 10.3389/fgene.2022.819699

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Copyright © 2022 He, Zhang, Han, Su, Zhao, Wang, Wang, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPARCL1 is the direct target of miRNA-105-5p. (A) Venn diagram of downregulated DEmRNAs and the predicted target mRNAs of miRNA-105-5p; (B) Correlation of miRNA-105-5p and the 10 overlapping mRNAs; (C) SPARCL1 expression in TCGA-ESCC dataset; (D) SPARCL1 expression in cancer and adjacent normal tissue; (E) SPARCL1 level in normal human esophageal epithelial cell line and ESCC cell lines; (F) Putative binding sites between miRNA-105-5p and SPARCL1; (G) The targeting relationship between miRNA-105-5p and SPARCL1; (H) The effect of silencing/overexpressing miRNA-105-5p in ESCC cells on SPARCL1 level; *p < 0.05, **p < 0.01.