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. 2022 Mar 3;13:819699. doi: 10.3389/fgene.2022.819699

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Copyright © 2022 He, Zhang, Han, Su, Zhao, Wang, Wang, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPARCL1 inhibits ESCC cell progression by modulating FAK/Akt signaling pathway. (A) GSEA result of SPARCL1; (B) The protein expression levels of SPARCL1 and FAK/Akt signaling pathway-related proteins in ESCC cells upon SPARCL1 overexpression; (C) The protein expression levels of SPARCL1 and FAK/Akt signaling pathway-related proteins in ESCC cells with an addition of p-Akt activator SC-79; (D–F) CCK-8 assay (D), wound healing assay (40×), and (E) Transwell invasion assay (×100) (F) were carried out to evaluate whether SPARCL1 suppresses ESCC cell proliferation, migration, and invasion via FAK/Akt signaling pathway; *p < 0.05.