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. 2022 Mar 3;13:819699. doi: 10.3389/fgene.2022.819699

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Copyright © 2022 He, Zhang, Han, Su, Zhao, Wang, Wang, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum EV-derived miRNA-105-5p fosters ESCC cell growth in vivo by targeting SPARCL1 and regulating FAK/Akt signaling pathway. (A) Tumors of nude mice that were injected with PBS or serum EVs of ESCC patients; (B) Growth curves of tumors of nude mice; (C) Tumor weight of nude mice; (D) MiRNA-105-5p expression in tumors of nude mice; and (E) The protein expression of SPARCL1 and proteins related to FAK/Akt signaling pathway in tumors of nude mice (×200); *p < 0.05.