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. 2022 Mar 16;5(7):e202201415. doi: 10.26508/lsa.202201415

Figure 4. Spike N-terminal domain (NTD) mutation profiles and the residues targeted by neutralizing antibodies.

Figure 4.

(A) Number of GISAID strains harboring mutations on the NTD compared to the Wuhan strain. (B) The cumulative number of interactions at the interface of 17-nABs and spike NTD residues predicted using the Prodigy web server. (C) Mapping of highly interacting residues (red) on the NTD (14–305) (cyan) of the SARS-CoV-2 spike (PDB ID: 7JJI). The receptor-binding domain (330–675) of the spike denoted in yellow. (D) Expanded view of S2X333 Fab (PDB ID: 7LXY) and S2M28 Fab (PDB ID: 7LY2) interactions with NTD residues. The residues at the Fab–NTD interface have been shown as sticks. Oxygen atoms in orange, nitrogen atoms in blue, and polar interactions between the interacting residues have been shown as red dashed lines.