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. 2022 Mar 3;13:847634. doi: 10.3389/fmicb.2022.847634

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Copyright © 2022 Chen, Yang, Dai, Yi, Peng, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistance to SCF and metabolic profile in PA-R_SCF. (A) MIC of PA-S and PA-R_SCF strains. (B) Abundance correlation of metabolites quantified in two technical replicates with high reproducibility. Metabolite abundance was represented in log₁₀. (C) Categories of the metabolites in PA-S and PA-R_SCF. (D) Heatmaps of unsupervised hierarchical clustering of differential metabolites in PA-S and PA-R_SCF (row). Blue and yellow indicate lower and higher expression of the metabolites relative to the mean and standard deviation of the row metabolite level, respectively (see color scale).