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. 2022 Mar 3;13:847634. doi: 10.3389/fmicb.2022.847634

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Copyright © 2022 Chen, Yang, Dai, Yi, Peng, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the depressed central carbon metabolism. (A) Map showing that the composition of central carbon metabolism includes glycolysis, PPP, ED pathway, and P cycle. G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; 6PG, 6-phosphogluconate; KDPG, 2-keto-3-deoxy-6-phosphogluconate; Ri5P, ribulose-5-phosphate; X5P, xylulose-5-phosphate; G3P, glyceraldehyde-3-phosphate; PEP, phosphoenolpyruvate; HK, hexokinase; PK, pyruvate kinase; PDH, pyruvate dehydrogenase; KGDH, alpha-ketoglutarate dehydrogenase; SDH, succinate dehydrogenase; MDH, malate dehydrogenase; G6PDH, glucose 6-phsophate dehydrogenase; 6PGDH, 6-phosphogluconate dehydrogenase. Solid lines represent single-step reaction and dashed lines represent multistep reaction. Arrows indicate the direction of the reaction. (B) qRT-PCR for expression of key genes in glycolysis, PPP, and P cycle. (C) Activity of enzymes in glycolysis, PPP, and P cycle. Results are displayed as mean ± SEM and three biological repeats are performed. Significant differences are identified. *p < 0.05 and **p < 0.01.