TABLE 1.

Serum or plasma miRNAs as IR biomarkers in human samples.

miRNAs	Material	Species	Predictors	References
miR-199a-5p↑	Serum	Human	Radiotherapy prognosis	Baek et al. (2020)
miR-218-5p↑	Serum	Human	—	Chen et al. (2021)
miR-29a-3p↓, miR-150-5p↓	Plasma	Human	IR-induced organ injury	Dinh et al. (2016)
miR-92a-1-5p↓, miR-25-5p↓, miR-1290↑	Serum	Human	Radiotherapy prognosis	Fan et al. (2020)
miR-34a↑	Serum	Human	Dose estimation	Halimi et al. (2016)
miR-26b-5p↓	Serum	Human	Radiotherapy prognosis	Han et al. (2020)
Combination of 16 miRNAs(e.g. miR-100-5p, miR-106b-5p, miR-145-5p)	Serum	Human	IR-induced organ injury	Hawkins et al. (2019)
miR-143↓	Serum	Human	Radiotherapy prognosis	Hiyoshi et al. (2017)
miR-1281↓, miR-6732-3p↓	Serum	Human	Radiosensitivity	Li et al. (2020a)
miR-6731-5p↑, miR-208b-3p↑, miR-2116-3p↓, miR-574-3p↓etc.	Exosomes in plasma	Human	Radiotherapy prognosis	Li et al. (2020b)
miR-130a↑, miR-25↑, miR-191*↑	Serum	Human, mouse	Radiotherapy prognosis	Lv et al. (2020)
Combination of miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p	Plasma	Human	Dose estimation	Summerer et al. (2013)
miR-142-3p, miR-186-5p, miR-195-5p, miR-374b-5p and miR-574-3p	Plasma	Human	Radiotherapy prognosis	Summerer et al. (2015)
Combination of 11 miRNAs(e.g. miR-10b-5p, miR-125b-5p, miR-126-3p)	Serum	Human	Radiosensitivity	Sun et al. (2018)
miR-208a↑, miR-200a-3p↓, miR-126-3p↓, miR-29b-3p↓	Serum	Human	—	Tang et al. (2016)
Combination of miR-425-5p, miR-185-5p	Serum	Human	IR-induced organ injury	Tomasik et al. (2021)
Combination of miR-155, miR-221	Serum	Human	IR-induced organ injury	Xu et al. (2014)
miR-345↓	Serum	Human	Radiotherapy prognosis	Yu et al. (2016)
miR-504↑	Serum	Human	Radiotherapy prognosis	Zhao et al. (2015)