TABLE 2.

Serum or plasma miRNAs as IR biomarkers in animal models.

miRNAs	Material	Species	Predictors	References
miR-130a-3p↑, miR-142-5p↓, miR-17-3p↓, miR-194-5p↑etc.	Serum	Mouse	IR-induced organ injury	Acharya et al. (2015)
↑: miR-329-3p,miR-1249-3p,miR-6366,miR-703,miR-344g-5p	Plasma	Mouse	Dose estimation	Bugden et al. (2019)
↓: let-7j, miR-20a-5p
↑: miR-714, miR-3971, miR-150-5p, miR-5120, miR-5104	Serum	Mouse	—	Chakraborty et al. (2020)
↓: miR-204-5p, miR-96-5p, miR-124-3p, miR-9-5p, miR-211-5p
miR-375-3p↑, miR-709↑	Serum	Mouse	IR-induced organ injury	Chiba et al. (2018)
miR34a↑, miR-142-5p↑etc.	Plasma	Mouse	Dose estimation	Cui et al. (2011)
miR-133b↑, miR-215↓, miR-375↑	Serum	Non-human primates	IR-induced organ injury	Fendler et al. (2017)
miR144-5p↑, miR-144-3p↑, miR-142-5p↑, miR-19a-3p↑	Whole blood	Rat	—	Gao et al. (2017)
miR-690↑, miR-223↑	Serum	Mouse	IR-induced organ injury	Islam et al. (2015)
miR-150↓, miR-200b↑, miR-762↑	Serum	Mouse	Dose estimation	Jacob et al. (2013)
miR-34a↑	Serum	Mouse	Dose estimation	Liu et al. (2011)
miR-150-5p↓, miR-574-5p↑, miR126↑, miR-144↑, miR-21↑, miR-1-3p↑, miR-206↑	Plasma	Non-human primates	Dose estimation	Menon et al. (2016)
Total miRNAs	Plasma	Mouse	Radiotherapy prognosis	Minnier et al. (2021)
miR-34a-5p, miR-34b-3p, miR-96-5p, miR-100-5p, miR-122-5p, miR-150-5p, miR-199a-5p, miR-199b-5p and miR-802-5p	Plasma	Mouse	Radiotherapy prognosis	Rogers et al. (2020)
miR-199a-3p, miR-25-3petc.	Plasma	Non-human primates	Radiotherapy prognosis	Rogers et al. (2021)
Combination of miR-183-5p, miR-9-3p, miR-200b-5p, miR-342-3p, miR-574-5p	Serum	Mouse	—	Wei et al. (2017)
miR-150-5p↓	Whole blood, serum	Mouse, human	Dose estimation	Yadav et al. (2020)
miR-101a↓, miR-103↓, miR-3096-5p↓, miR-652*↓	Serum	Mouse	IR-induced organ injury	Yamaguchi et al. (2019)
miR-151-3p↑, miR-128-3p↑	Exosomes in serum	Mouse	Dose estimation	Zhang et al. (2020)