FIGURE 1.

Phylogenetic tree of CoA transferase sequences shows the superfamily should be divided into six, not three families. (a) The three traditional CoA transferase families. Subfamilies of family I also shown. (b) Our six proposed families. The proposed families are consistent with other properties noted (see Figure 3 for names of enzymes and branch support values). Sequences in panel (a) were assigned to families based on descriptions in Reference [1] and to subfamilies based on Figure S1