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. 2022 Mar 3;12:780493. doi: 10.3389/fonc.2022.780493

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Copyright © 2022 Peng, Peng, Cai, Qiu, Lan, Luo, Yang, Xie, Du, Yuan, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of TM4SF1-AS1 knockdown in two STAD cells. (A–D) Volcano map showing the up- and down-regulated genes after TM4SF1-AS1 knockdown in AGS and MKN45 cells with two siRNA targets (siTM4SF1-AS1#3 and siTM4SF1-AS1#4). The red dots indicate up-regulated genes, and blue dots signify down-regulated genes. (E, F) Venn diagram displaying the differentially expressed genes by the intersection of siTM4SF1-AS1#3 and siTM4SF1-AS1#3 in (E) AGS and (F) MKN45 cells. (G, H) Heatmap showing the up- and down-regulated genes after TM4SF1-AS1 knockdown in (G) AGS and (H) MKN45 cells with siTM4SF1-AS1#3 and siTM4SF1-AS1#4. The red dots indicate up-regulated genes, and blue dots signify down-regulated genes. (I, J) GSEA analysis was performed on (I) AGS and (J) MKN45 cells following TM4SF1-AS1 knockdown. (K, L) KEGG analysis was performed on the changed genes in (K) AGS and (L) MKN45 cells after TM4SF1-AS1 knockdown with siRNAs. RNA-seq data of TM4SF1-AS1 knockdown in AGS MKN45 cells was from this paper.