Table 2.
Ventilator settings, ventilation at baseline, and pre-surfactant and post surfactant time.
| HFOV (n = 11) | HFOV+VG (n = 11) | p | |
|---|---|---|---|
| Baseline | |||
| MAP (cmH2O) | 9.7 ± 0.5 | 9.5 ± 0.8 | 0.35 |
| FiO2 | 0.43 ± 0.10 | 0.46 ± 0.10 | 0.96 |
| ΔP (cmH2O) | 20 ± 3 | 19 ± 1 | 0.32 |
| VThf (ml/kg) | 1.7 ± 0.3 | 1.7 ± 0.1 | 0.53 |
| DCO2 (ml2/kg2/s) | 46.5 ± 18.0 | 42.2 ± 16.1 | 0.46 |
| pCO2 (mmHg) | 50.5 ± 4.0 | 50.0 ± 3.2 | 0.73 |
| OI | 8.0 ± 2.3 | 8.4 ± 2.0 | 0.35 |
| Pre-surfactant | |||
| MAP (cmH2O) | 13.7 ± 1.4 | 13.9 ± 1.4 | 0.77 |
| FiO2 | 0.25 ± 0.01 | 0.25 ± 0.01 | 1 |
| ΔP (cmH2O) | 20 ± 3 | 18 ± 2 | 0.14 |
| VThf (ml/kg) | 1.8 ± 0.3 | 1.6 ± 0.1 | 0.03 |
| DCO2 (ml2/kg2/s) | 51.6 ± 16.3 | 39.4 ± 5.1 | 0.03 |
| pCO2 (mmHg) | 48.4 ± 3.2 | 48.0 ± 2.2 | 0.76 |
| Post-surfactant | |||
| MAP (cmH2O) | 8.7 ± 0.7 | 8.6 ± 0.7 | 0.88 |
| FiO2 | 0.21 ± 0.01 | 0.21 ± 0.01 | 0.75 |
| ΔP (cmH2O) | 17 ± 3 | 13 ± 3 | 0.005 |
| VThf (ml/kg) | 2.1 ± 0.3 | 1.6 ± 0.1 | <0.0001 |
| DCO2 (ml2/kg2/s) | 69.5 ± 16.4 | 39.5 ± 5.8 | <0.0001 |
| pCO2 (mmHg) | 43.1 ± 3.8 | 46.8 ± 1.5 | 0.006 |
Values expressed as mean ± SD. MAP, mean airways pressure; VThf (ml/kg), tidal volume HFOV; DCO2, coefficient of gas transport; FiO2, fraction of inspired oxygen; OI, oxygenation index (MAP x FiO2/PaO2x 100).
Bold values are the statistically significant p-values.