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. 2022 Mar 3;9:848930. doi: 10.3389/fnut.2022.848930

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Copyright © 2022 Hu, Zhang, Wang, Zhou, Pang, Cui, Ge, Liu, Huang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β-glucans promoted macrophage M2 polarization in the colon. (A) Immunohistochemical staining and quantification of colonic CD206-positive cells. (B) Immunohistochemical staining and quantification of colonic F4/80-positive cells. (C–F) mRNA expression levels of IL-10 (C), IL-6 (D), TNF-α (E), IL-1β (F) in the colon of mice. (G–I) Pearson's correlation analysis between CD206 positive cells in colon and discrimination index (G), Iba1⁺cells in the hippocampus (H) and in the PFC (I). If P < 0.05 for significant correlations, R is noted. (J–L) Pearson's correlation analysis between IL-10 mRNA expression in colon and discrimination index (J), Iba1⁺cells in the hippocampus (K) and Iba1⁺cells in the PFC (L). If P < 0.05 for significant correlations, R is noted. All n = 6. Data were presented as mean ± SEM. *P < 0.05 vs. Control, **P < 0.01 vs. Control, ***P < 0.001 vs. Control. Scale bar: 80 μm.