Figure 1.

Identification of differential metabotypes associated with schizophrenia. (A) The orthogonal partial least squares discriminant analysis (OPLS-DA) model was used to discriminate between 63 SCZ subjects (blue boxes) and 57 HCs (yellow diamonds). (B) Permutation test showing the original R2 and Q2 values (top right) as significantly higher than corresponding permuted values (bottom left), demonstrating the OPLS-DA model’s robustness. (C) Average relative intensities of the 18 co-abundance metabotypes (clusters) between the two groups. Red and green represented relatively high and low densities, respectively. The asterisk represented a significant negative correlation between the metabotype and the duration of illness (P-value < 0.05). .