TABLE 5.
Sensitivity analyses of adjusted hazard ratios of renin-angiotensin inhibitor use for Parkinson’s disease.
| Number of subjects | Person-years | Number of events | Incidence rate a | Adjusted HR (95% Cl) b | |
|---|---|---|---|---|---|
| Shifting the index date | |||||
| July 1. 2009. (main) | 31,114 | 239,923 | 490 | 2.04 | 0.75 (0.66–0.85) |
| July 1. 2010 | 43,130 | 304,837 | 615 | 2.02 | 0.78 (0.70–0.87) |
| July 1. 2011 | 48,050 | 306,441 | 593 | 1.94 | 0.77 (0.69–0.86) |
| Lengthening lagged period | |||||
| 1-year lagged period (main) | 31,114 | 239,923 | 490 | 2.04 | 0.75 (0.66–0.85) |
| 3-year lagged period | 28,001 | 176,266 | 368 | 2.09 | 0.81 (0.71–0.94) |
| 5-year lagged period | 25,283 | 121,748 | 242 | 1.99 | 0.76 (0.64–0.90) |
| Changing the outcome definition | |||||
| ICD-10 + drug prescription+ PD registration code (main) | 31,114 | 239,923 | 490 | 2.04 | 0.75 (0.66–0.85) |
| ICD-10 + PD registration code | 31,119 | 239,864 | 521 | 2.17 | 0.81 (0.72–0.91) |
| ICD-10 + drug prescription (≥60 days) | 31,145 | 239,907 | 569 | 2.37 | 0.83 (0.74–0.93) |
CI, confidence interval; HR, hazard ratio; ICD-10, International Classification of disease 10th Revision; PD, Parkinson’s disease.
a
The incidence rate was presented per 1,000 person-years.
b
Adjusted for all covariates presented in Table 2 with a multivariate Cox proportional hazard model for Parkinson’s disease.