. Author manuscript; available in PMC: 2023 Mar 10.

Published in final edited form as: Alcohol Clin Exp Res. 2022 Mar 10;46(3):374–383. doi: 10.1111/acer.14772

Table 4:

Associations between PRS (both continuous and dichotomized (top 10% vs. 90%)) and AUD; also shown is the association between the first-degree family history and AUD.

sample	Testing variable	Dichotomized PRS			Continuous PRS
sample	Testing variable	OR	95%CI	P-value	beta	SE	P-value
having FH information	FH^*	2.99	2.23–4.00	1.67E-13	NA	NA	NA
FH+	PRS	1.86	1.35–2.56	1.32E-04	2.43	0.47	2.93E-07
FH?	PRS	1.50	0.98–2.29	0.06	2.91	0.60	1.51E-06
FH−	PRS	0.45	0.12–1.69	0.23	2.64	1.87	0.16
Full sample	PRS	1.96	1.54–2.51	7.57E-08	3.17	0.38	2.66E-16

Note:

^*:

first-degree family history. P-values were calculated from generalized linear mixed models with the logit link function. Significant P-values (<6.25E-03) are in bold.