Morphology of regenerated skin upon wound closure. [A]Representative H&E staining images of wound biopsy samples at Days 7, 14 and 21. (Arrows: Yellow- Neovascularisation, Red- Inflammatory cells, Black- Glandular Adnexa).Scale bar: 100 μm. [B] Granulation tissue thickness (in mm) of wound healing after treatment applications. [C] Histomorphometrical analysis of angiogenesis. Blood vessel (hpf -High powered field) formation in wound biopsy samples. Results expressed as mean ± SD (n = 3, ∗P < 0.05). Treatments: Control (0.1 M PBS, pH 7.4), LLKKK18 – Chitosan NP (LLKKK18 peptide entrapped Chitosan nanoparticles), Tylotoin – Chitosan MP (Tylotoin peptide entrapped Chitosan microparticles), PLGA/Collagen-NF (PLGA/Collagen nanofibers), NF-NP-MP (Bioactive peptides laden nano/micro-sized particles enriched PLGA/Collagen nano-fiber mat).