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. 2022 Mar 3;13:852176. doi: 10.3389/fmicb.2022.852176

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Copyright © 2022 Webby, Williams-Jones, Press and Kleanthous.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tol-pal suppressor and co-conservation analysis suggest the transmembrane helix of TolA docks within a groove formed by two TolQ helices. (A) The organization of TolQ helices (numbered) relative to the TolA transmembrane helix (green) within the TolQ-TolA model. Individual TolQ monomers are labeled in yellow and orange, respectively. The position of the TolA SHLS motif and suppressor mutations identified previously in TolQ (G26, I29 and A30 helix 2, labeled red) (Germon et al., 1998). (B,C) Maximum co-conservation scores of TolQ-TolA from RaptorX output mapped onto the TolQ-TolA model. The face of the TolA transmembrane helix in contact with TolQ in the model is strongly co-conserved. The TolQ helix 2 groove shows high co-conservation with the transmembrane helix of TolA (yellow outline).