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. 2022 Mar 15;14:17588359221083956. doi: 10.1177/17588359221083956

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© The Author(s), 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — AMEERA-5 study design. Randomization will be stratified by de novo metastatic disease (yes or no), menopausal status (yes or no), and visceral metastasis defined by at least one of the following: liver, lung, or brain metastasis or pleural or peritoneal involvement (yes or no).

PO, oral; QD, once daily; SQ, subcutaneous.

^aArchived tissue or fresh sample obtained between screening and cycle 1 day 1.

^bPre-/perimenopausal women and men will receive a subcutaneous goserelin implant (3.6 mg) on day 1 of every 28-day cycle.