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. 2022 Mar 16;8(1):e002195. doi: 10.1136/rmdopen-2022-002195

Figure 2.

Figure 2

Proportions of patients achieving (A) ACR50 and (B) ACR70 responses at week 24 and week 52 by patient demographics, disease characteristics and csDMARD use at baseline. Week 24 response rates (NRI) are compared between guselkumab (GUS) and placebo (PBO) via ORs and 95% CIs (depicted via forest plot; actual values provided in online supplemental table 1). Week 52 response rates (NRI) for GUS Q4W and GUS Q8W were determined to assess durability of ACR50 and ACR70 response rates within each patient subgroup. Prior to week 24, patients meeting treatment failure criteria were considered non-responders. Missing data through Weeks 24 and 52 were imputed as non-response. ACR50/70, American College of Rheumatology 50/70% improvement; BMI, body mass index; CI, confidence interval; CRP, C reactive protein; csDMARD, conventional synthetic disease-modifying antirheumatic drug; MTX, methotrexate; NRI, non-responder imputation; OR, odds ratio; PsA, psoriatic arthritis; Q4W/Q8W, every 4 weeks/every 8 weeks.