Figure 4.

Proportions of patients achieving (A) FACIT-Fatigue response (≥4-point improvement in FACIT-F score from baseline) and (B) HAQ-DI response (≥0.35-point improvement in HAQ-DI score from baseline among patients with a HAQ-DI score ≥0.35 at baseline) at week 24 and week 52 by patient demographics, disease characteristics and csDMARD use at baseline. Week 24 response rates (NRI) are compared between guselkumab (GUS) and placebo (PBO) via ORs and 95% CIs (depicted via forest plot; actual values provided in online supplemental table 3). Week 52 response rates (NRI) for GUS Q4W and GUS Q8W were determined to assess durability of FACIT-F and HAQ-DI response rates within each patient subgroup. Prior to week 24, patients meeting treatment failure criteria were considered non-responders. Missing data through weeks 24 and 52 were imputed as non-response. BMI, body mass index; CI, confidence interval; CRP, C reactive protein; csDMARD, conventional synthetic disease-modifying antirheumatic drug; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; HAQ-DI, Health Assessment Questionnaire Disability Index; MTX, methotrexate; NRI, non-responder imputation; OR, odds ratio; PsA, psoriatic arthritis; Q4W/Q8W, every 4 weeks/every 8 weeks.